A 47-year-old male was referred for evaluation presenting a painless palatal lesion, noticed by his dentist one year ago. Medical history revealed no relevant information. Clinical examination showed a 6 mm shallow depression with small papillary projections on the left side of the hard palate close to palatal gingiva of the second molar. Periapical radiographs showed no alterations on the adjacent bone. The clinical provisional diagnosis was human papillomavirus associated lesion. A conservative surgical procedure removing the entire lesion was performed under local anesthesia and the post-operatory period was uneventful.